Fate of RBC/ fate of
Haemoglobin
As RBC is mature and aged, the metabolic system of
the RBC become progressively less active and the cell become more fragile. Many of the RBC are self destroyed in
the spleen where they squeeze through the red pulp of the spleen.
As the erythrocyte are
destroyed the iron containing moiety of hemoglobin is conserved and the
pigmentary part is converted into bile pigment. Hemoglobin is phagocytosis by
macrophage in many part of the body (kupffer cell in
liver, macrophage of spleen and bone marrow). It release iron and
prophyrin portion.
The propyrin portion of Hb is converted into biliverdin.
The biliverdin is converted into bilirubin. It
is transported by albumin to the liver where it undergoes conjugation with
glucuronyl transferase thus forming conjugated bilirubin. The conjugated
bilirubin is passed into the duodenum through hepato-pancreatic ducts.
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